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Product information "Ribavirin 5'-monophosphate (lithium salt)"
Ribavirin 5'-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin (Cay-16757), exhibits broad-spectrum antiviral activity, particularly against myxoviruses. The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase. The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5'-monophosphate.Formal Name: 1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, dilithium salt. CAS Number: 66983-94-6. Molecular Formula: C8H11N4O8P . 2Li. Formula Weight: 336.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 205 nm. SMILES: O[C@@H]1[C@@H](COP([O-])([O-])=O)O[C@@H](N2N=C(C(N)=O)N=C2)[C@@H]1O.[Li+].[Li+]. InChi Code: InChI=1S/C8H13N4O8P.2Li/c9-6(15)7-10-2-12(11-7)8-5(14)4(13)3(20-8)1-19-21(16,17)18,,/h2-5,8,13-14H,1H2,(H2,9,15)(H2,16,17,18),,/q,2*+1/p-2/t3-,4-,5-,8-,,/m1../s1. InChi Key: SIMMZIYZANJRNU-DAVOPPATSA-L.
Keywords:
1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, dilithium salt
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