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Resibufogenin is a cardiac glycoside first isolated from Bufonis venom that acts as an inhibitor of the Na+/K+-ATPase. It exhibits cardiotonic, vasopressor, and respiratory stimulating actions in both animal and clinical models. Resibufogenin has been used to antagonize the action of marinobufagenin in a rat experimental model of preeclampsia. Resibufogenin is also reported to have antiproliferative effects against cancer cells, inducing cell cycle arrest by suppressing the expression of cyclin D1.Formal Name: (3beta,5beta,15beta)-14,15-epoxy-3-hydroxy-bufa-20,22-dienolide. CAS Number: 465-39-4. Synonyms: Bufogenin, NSC 90783, Respigon. Molecular Formula: C24H32O4. Formula Weight: 384.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/mL, DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL, DMSO: 20 mg/mL, Ethanol: 5 mg/mL. lambdamax: 299 nm. SMILES: O=C(C=C1)OC=C1[C@H]2C[C@@H]3[C@]4(O3)[C@]5([H])CC[C@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@@]42C. InChi Code: InChI=1S/C24H32O4/c1-22-9-7-16(25)11-15(22)4-5-18-17(22)8-10-23(2)19(12-20-24(18,23)28-20)14-3-6-21(26)27-13-14/h3,6,13,15-20,25H,4-5,7-12H2,1-2H3/t15-,16+,17+,18-,19-,20-,22+,23-,24-/m1/s1. InChi Key: ATLJNLYIJOCWJE-CWMZOUAVSA-N.
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