RC363

RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol (Cay-15043). It reduces 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals by approximately 40% in a cell-free assay when used at a concentration of 25 µM. RC363 prevents glutamate-induced toxicity in HT22 cultured hippocampal cells (IC50 = 234.5 nM) but does not reduce oxidant levels in these cells. It increases the levels of glutathione peroxidase 1 (GPX1) and the activity of GPX in glutamate-challenged HT22 cells when used at a concentration of 3 µM. RC363 inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells (IC50 = 173.6 nM).Formal Name: 2,6-bis(1,1-dimethylethyl)-4-(2-thienylthio)-phenol. CAS Number: 2584411-86-7. Molecular Formula: C18H24OS2. Formula Weight: 320.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:1): insouble, PBS (pH 7.2): insouble. lambdamax: 249 nm. SMILES: OC1=C(C(C)(C)C)C=C(SC2=CC=CS2)C=C1C(C)(C)C. InChi Code: InChI=1S/C18H24OS2/c1-17(2,3)13-10-12(21-15-8-7-9-20-15)11-14(16(13)19)18(4,5)6/h7-11,19H,1-6H3. InChi Key: NGMIDNYWQLUYJB-UHFFFAOYSA-N.