RB394

RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARgamma that inhibits sEH with an IC50 of 0.33 µM and activates PPARgamma with an EC50 of 0.3 µM. It is inactive at PPARdelta and shows 29% activation of PPARalpha, relative to control, at 10 µM. RB394 is water soluble, orally bioavailable, and can be delivered through drinking water. In a two week in vivo pharmacokinetic study in mice, 30 mg/kg body weight in drinking water resulted in a final plasma concentration of ~3 µM. This coincided with upregulation of PPARgamma target genes, as well as PPARalpha and PPARdelta, in mouse livers.Formal Name: alpha-ethyl-4-[[[[4-methoxy-2-(trifluoromethyl)phenyl]methyl]amino]carbonyl]-benzenepropanoic acid. CAS Number: 1830320-32-5. Molecular Formula: C21H22F3NO4. Formula Weight: 409.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25mg/mL, DMSO: 33mg/mL, DMSO:PBS (pH 7.2) (1:20): .04 mg/mL, Ethanol: 5mg/mL. lambdamax: 232, 280 nm. SMILES: COC1=CC(C(F)(F)F)=C(CNC(C2=CC=C(CC(C(O)=O)CC)C=C2)=O)C=C1. InChi Code: InChI=1S/C21H22F3NO4/c1-3-14(20(27)28)10-13-4-6-15(7-5-13)19(26)25-12-16-8-9-17(29-2)11-18(16)21(22,23)24/h4-9,11,14H,3,10,12H2,1-2H3,(H,25,26)(H,27,28). InChi Key: VPAHYLNIDWFBPW-UHFFFAOYSA-N.