Raloxifene (hydrochloride)

Raloxifene is a selective estrogen receptor modulator (SERM) that binds to the estrogen receptor with an IC50 value of 0.4 nM. It exhibits estrogenic activity in bone cells without stimulating breast or uterine tissues. Raloxifene guards endothelial cells obtained from rat aortic rings against oxidative insult (1 µM) and lowers serum cholesterol in ovariectomized rodents (ED50 = 0.2 mg/kg). Raloxifene also inhibits the voltage-gated potassium channel Kv4.3 in an estrogen-independent manner (IC50 = 2 µM). Formulations containing raloxifene have been shown to reduce bone resorption and promote bone formation in post-menopausal women.Formal Name: [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone, monohydrochloride. CAS Number: 82640-04-8. Synonyms: Keoxifene, LY156758. Molecular Formula: C28H27NO4S . HCl. Formula Weight: 510.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 222, 287 nm. SMILES: OC1=CC=C(C(C(C2=CC=C(OCCN3CCCCC3)C=C2)=O)=C(C4=CC=C(O)C=C4)S5)C5=C1.Cl. InChi Code: InChI=1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29,/h4-13,18,30-31H,1-3,14-17H2,1H. InChi Key: BKXVVCILCIUCLG-UHFFFAOYSA-N.