(R)-Ibuprofen

(R)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and an isomer of (±)-ibuprofen (Cay-70280). Unlike (S)-ibuprofen (Cay-16793), (R)-ibuprofen does not inhibit COX-1 or COX-2 in vitro (IC50s = 360 and 15.6 µM, respectively) but is converted to the active (S)-enantiomer in vivo. It inhibits NF-kappaB transactivation in a reporter assay using Jurkat T cells (IC50 = 121.8 µM). (R)-Ibuprofen decreases superoxide formation and beta-glucuronidase release induced by N-formyl-Met-Leu-Phe (fMLP, Cay-21495), as well as leukotriene B4 (LTB4, Cay-20110) formation induced by calcimycin (A23187, Cay-11016), in human polymorphonuclear (PMN) cells (IC50s = 0.43, 0.58, and 0.22 µM, respectively). Formulations containing (±)-ibuprofen have been used in the treatment of fever and mild-to-severe pain.Formal Name: alphaR-methyl-4-(2-methylpropyl)-benzeneacetic acid. CAS Number: 51146-57-7. Synonyms: (-)-Ibuprofen. Molecular Formula: C13H18O2. Formula Weight: 206.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 45 mg/ml, DMSO: 50 mg/ml, Ethanol: 60 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 220 nm. SMILES: OC([C@H](C)C1=CC=C(CC(C)C)C=C1)=O. InChi Code: InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m1/s1. InChi Key: HEFNNWSXXWATRW-SNVBAGLBSA-N.