Quinacrine analog 34

Quinacrine analog 34 is an inhibitor of autophagy with a minimum effective concentration (MEC) of 0.5 µM in U2OS cells. It induces lysosomal deacidification and accumulation of LC3-II in the same cells when used at concentrations of 0.5 or 3 µM.Formal Name: 6-chloro-1,2,3,4-tetrahydro-N-[2-(4-methyl-1-piperazinyl)ethyl]-9-acridinamine. CAS Number: 1411646-44-0. Molecular Formula: C20H27ClN4. Formula Weight: 358.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 226, 252, 330 nm. SMILES: ClC1=CC=C2C(N=C(CCCC3)C3=C2NCCN4CCN(C)CC4)=C1. InChi Code: InChI=1S/C20H27ClN4/c1-24-10-12-25(13-11-24)9-8-22-20-16-4-2-3-5-18(16)23-19-14-15(21)6-7-17(19)20/h6-7,14H,2-5,8-13H2,1H3,(H,22,23). InChi Key: AKZZUONQDIGIBX-UHFFFAOYSA-N.