QNZ

Nuclear factor-kappaB (NF-kappaB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-alpha, IL-1beta, IL-6, and IL-8. QNZ is an inhibitor of NF-kappaB activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNF-alpha production from lipopolysaccharide-stimulated mouse splenocytes with an IC50 of 7 nM. QNZ showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.Formal Name: N4-[2-(4-phenoxyphenyl)ethyl]-4,6-quinazolinediamine. CAS Number: 545380-34-5. Synonyms: CAY10470. Molecular Formula: C22H20N4O. Formula Weight: 356.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. SMILES: NC1=CC2=C(N=CN=C2NCCC3=CC=C(OC4=CC=CC=C4)C=C3)C=C1. InChi Code: InChI=1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26). InChi Key: IBAKVEUZKHOWNG-UHFFFAOYSA-N.