PSB-603

PSB-603 is an antagonist of the adenosine A2B receptor (Ki = 0.553 nM). It is selective for adenosine A2B over A1, A2A, and A3 receptors (Kis = >10,000 nM). It reduces intracellular calcium concentrations in Jurkat T cells expressing the human A2B receptor (IC50 = 1.13 nM). PSB-603 reduces Zika viral plaque formation (IC50 = 43.8 nM) without affecting cell viability of A549 cells when used at concentrations up to 1 µM. In vivo, PSB-603 (0.25 µg/head, i.p.) delays tumor growth and reduces tumor volume and the number of pulmonary metastases in the B16 mouse model of melanoma via inhibition of induction of regulatory T cells.Formal Name: 8-[4-[[4-(4-chlorophenyl)-1-piperazinyl]sulfonyl]phenyl]-3,9-dihydro-1-propyl-1H-purine-2,6-dione. CAS Number: 1092351-10-4. Molecular Formula: C24H25ClN6O4S. Formula Weight: 529.0. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: slightly soluble. lambdamax: 252, 328 nm. SMILES: O=S(C1=CC=C(C2=NC(NC(N(CCC)C3=O)=O)=C3N2)C=C1)(N4CCN(C5=CC=C(Cl)C=C5)CC4)=O. InChi Code: InChI=1S/C24H25ClN6O4S/c1-2-11-31-23(32)20-22(28-24(31)33)27-21(26-20)16-3-9-19(10-4-16)36(34,35)30-14-12-29(13-15-30)18-7-5-17(25)6-8-18/h3-10H,2,11-15H2,1H3,(H,26,27)(H,28,33). InChi Key: OVHCTHHFOHMNFV-UHFFFAOYSA-N.