PSB-1115 (potassium salt)

PSB-1115 is an antagonist of the adenosine A2B receptor (Ki = 53.4 nM). It is selective for A2B over A1 and A2A receptors, which have Ki values of 2,200 and 24,000 nM, respectively, and over the A3 receptor, which it inhibits only 14% at a concentration of 10 µM. PSB-1115 pre-treatment reduces relaxation of rat trachea induced by repeated dosing of the non-selective adenosine agonist NECA (Cay-21420).Formal Name: 4-(2,3,6,9-tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-benzenesulfonic acid, monopotassium salt. CAS Number: 409344-71-4. Molecular Formula: C14H13N4O5S . K. Formula Weight: 388.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 25 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 238, 312 nm. SMILES: O=C1N(CCC)C(C(NC(C2=CC=C(S([O-])(=O)=O)C=C2)=N3)=C3N1)=O.[K+]. InChi Code: InChI=1S/C14H14N4O5S.K/c1-2-7-18-13(19)10-12(17-14(18)20)16-11(15-10)8-3-5-9(6-4-8)24(21,22)23,/h3-6H,2,7H2,1H3,(H,15,16)(H,17,20)(H,21,22,23),/q,+1/p-1. InChi Key: CJOWSBOERSTJAR-UHFFFAOYSA-M.