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Procysteine is a prodrug form of cysteine that is metabolized to cysteine intracellularly and has antioxidant activity. It reduces TNF-alpha-induced increases in the expression of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in ARPE-19 human retinal pigment epithelial cells when used at a concentration of 0.5 mM. Procysteine (6.5 mmol/kg) also increases liver glutathione (GSH) levels in fasted, but not fed, mice. It reduces the production of reactive oxygen species (ROS) in bronchoalveolar lavage fluid (BALF) and decreases plasma extravasation in the lungs, as well as reverses decreases in the levels of hypoxia-inducible factor (HIF-1alpha) in a mouse model of allergic asthma when administered at doses of 80 and 160 mg/kg.Formal Name: 2-oxo-(4R)-4-thiazolidinecarboxylic acid. CAS Number: 19771-63-2. Synonyms: L-2-oxothiazolidine-4-Carboxylic Acid, L-2-oxothiazolidine-4-Carboxylate, OTC. Molecular Formula: C4H5NO3S. Formula Weight: 147.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: [H]N([C@H](C(O)=O)CS1)C1=O. InChi Code: InChI=1S/C4H5NO3S/c6-3(7)2-1-9-4(8)5-2/h2H,1H2,(H,5,8)(H,6,7). InChi Key: BMLMGCPTLHPWPY-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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