PRMT4/CARM1 Inhibitor

PRMT4/CARM1 Inhibitor selectively blocks the activity of PRMT4/CARM1 with an IC50 value of 7.1 µM. It displays very low affinity towards PRMT1 and SET7 with IC50 values of 63 and 943 µM, respectively. In human prostate cancer LNCaP cells, this compound reduced the prostate-specific antigen promoter activity at 8-10 µM.Formal Name: 3,5-bis[(3-bromo-4-hydroxyphenyl)methylene]-1-(phenylmethyl)-4-piperidinone. CAS Number: 1020399-49-8. Synonyms: Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor. Molecular Formula: C26H21Br2NO3. Formula Weight: 555.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL, Ethanol: 0.25 mg/mL. lambdamax: 250, 367 nm. SMILES: BrC1=CC(/C=C2CN(CC3=CC=CC=C3)C/C(C\2=O)=C\C4=CC(Br)=C(O)C=C4)=CC=C1O. InChi Code: InChI=1S/C26H21Br2NO3/c27-22-12-18(6-8-24(22)30)10-20-15-29(14-17-4-2-1-3-5-17)16-21(26(20)32)11-19-7-9-25(31)23(28)13-19/h1-13,30-31H,14-16H2/b20-10+,21-11+. InChi Key: KNMFTTWVELIVCC-CLVAPQHMSA-N.