Prazosin (hydrochloride)

Prazosin (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15023-50 50 mg -

6 - 10 business days*

43.00€
Cay15023-100 100 mg -

6 - 10 business days*

77.00€
Cay15023-250 250 mg -

6 - 10 business days*

156.00€
Cay15023-500 500 mg -

6 - 10 business days*

287.00€
 
Prazosin is an antagonist of alpha1-adrenergic receptors (alpha1-ARs). It selectively binds to... more
Product information "Prazosin (hydrochloride)"
Prazosin is an antagonist of alpha1-adrenergic receptors (alpha1-ARs). It selectively binds to alpha1-ARs with Ki values of 0.2, 0.25, and 0.32 nM for the human recombinant alpha1A-, alpha1B-, and alpha1D-ARs, respectively, over alpha2-ARs (Kis = 340 and 3.7 nM in alpha2A-AR-expressing HT-29 cells and alpha2B-AR-expressing NG108 cells, respectively). It also binds to melatonin receptor 3 (MT3) in hamster brain membranes (IC50 = 7.8 nM). Prazosin inhibits peripheral and central postsynaptic alpha1-ARs with IC50 values of 0.2 and 1.7 nM in isolated dog aorta and rat brain, respectively. It decreases diastolic blood pressure in normal, renal hypertensive, and spontaneously hypertensive rats when administered at a dose of 1 mg/kg. Prazosin (1.5 mg/kg) increases the number of entries and percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in alcohol-consuming rats and also reduces alcohol intake and alcohol-seeking behavior in alcohol-preferring rats.Formal Name: [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-methanone, monohydrochloride. CAS Number: 19237-84-4. Synonyms: CP 12,299-1, NSC 292810. Molecular Formula: C19H21N5O4 . HCl. Formula Weight: 419.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.1 mg/ml. lambdamax: 214, 247, 330, 342 nm. SMILES: COC(C(OC)=C1)=CC2=C1C(N)=NC(N3CCN(C(C4=CC=CO4)=O)CC3)=N2.Cl. InChi Code: InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14,/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22),1H. InChi Key: WFXFYZULCQKPIP-UHFFFAOYSA-N.
Keywords: CP 12,299-1, NSC 292810, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-methanone, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 15023

Properties

Application: Antihypertensive agent, melatonin MT3 receptor antagonist
MW: 419.9 D
Formula: C19H21N5O4 . HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 19237-84-4| Matching products
KEGG ID : K04135 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335, H361
P Phrases: P201, P202, P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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