PR-619

PR-619 is a general inhibitor of deubiquitylating enzymes (DUBs), significantly reducing the activity of a panel of DUBs with EC50 values ranging from 5-20 µM. It is cell-permeable and reversible in its action. It is selective for DUBs over other proteases. PR-619 induces the accumulation of polyubiquitinated proteins in cells, including those not involved in the ubiquitin-proteasome system. It is used to study the role of DUBs in diverse pathways, including protein turnover and neurodegeneration.Formal Name: thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester. CAS Number: 2645-32-1. Synonyms: 2,6-Diamino-3,5-dithiocyanopyridine, DUB Inhibitor V. Molecular Formula: C7H5N5S2. Formula Weight: 223.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 220, 266, 320 nm. SMILES: NC1=NC(N)=C(SC#N)C=C1SC#N. InChi Code: InChI=1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12). InChi Key: ZXOBLNBVNROVLC-UHFFFAOYSA-N.