PKCbeta Inhibitor

PKCbeta inhibitor is an inhibitor of PKCbeta1 and PKCbeta2 (IC50s = 21 and 5 nM, respectively). It is selective for PKCbeta1 and PKCbeta2 over PKCalpha, PKCepsilon, and PKCgamma (IC50s = 331, 2,807, and >1,000 nM, respectively), as well as JAK1, JAK2, and tyrosine kinase 2 (TYK2, IC50s = 770, 3,850, and 2,310 nM, respectively), but also inhibits JAK3 (IC50 = 17 nM)., PKCbeta inhibitor (14 µM) induces apoptosis and inhibits cell cycle progression in 2F7 AIDS-related Burkitt's lymphoma cells.Formal Name: 3-[1-[3-(1H-imidazol-1-yl)propyl]-1H-indol-3-yl]-4-(phenylamino)-1H-pyrrole-2,5-dione. CAS Number: 257879-35-9. Synonyms: Protein Kinase Cbeta Inhibitor. Molecular Formula: C24H21N5O2. Formula Weight: 411.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 0.25 mg/ml. lambdamax: 226 nm. SMILES: O=C1NC(C(C2=CN(CCCN3C=NC=C3)C4=C2C=CC=C4)=C1NC5=CC=CC=C5)=O. InChi Code: InChI=1S/C24H21N5O2/c30-23-21(22(24(31)27-23)26-17-7-2-1-3-8-17)19-15-29(20-10-5-4-9-18(19)20)13-6-12-28-14-11-25-16-28/h1-5,7-11,14-16H,6,12-13H2,(H2,26,27,30,31). InChi Key: KIWODJBCHRADND-UHFFFAOYSA-N.