Phenylbutazone

Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide). It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis. Formulations containing phenylbutazone have been used in the treatment of lameness in horses.Formal Name: 4-butyl-1,2-diphenyl-3,5-pyrazolidinedione. CAS Number: 50-33-9. Molecular Formula: C19H20N2O2. Formula Weight: 308.4. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 50 mg/ml, H2O: 1 mg/ml, PBS pH 7.2: .5 mg/ml. lambdamax: 242 nm. SMILES: CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O. InChi Code: InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3. InChi Key: VYMDGNCVAMGZFE-UHFFFAOYSA-N. Origin: Synthetic.