Pentosidine (trifluoroacetate salt)

Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling. Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of this AGE is catabolized before excretion.Formal Name: alphaS-amino-2-[[4S-amino-4-carboxybutyl]amino]-4H-imidazo[4,5-b]pyridine-4-hexanoic acid, trifluoroacetate salt. CAS Number: 225784-09-8. Molecular Formula: C17H26N6O4 . CF3COOH. Formula Weight: 492.4. Purity: >98%. Formulation: (Request formulation change), Lyophilized. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: [H]N(CCC[C@H](N)C(O)=O)C1=NC2=CC=CN(CCCC[C@H](N)C(O)=O)C2=N1.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C17H26N6O4.C2HF3O2/c18-11(15(24)25)5-1-2-9-23-10-4-7-13-14(23)22-17(21-13)20-8-3-6-12(19)16(26)27,3-2(4,5)1(6)7/h4,7,10-12H,1-3,5-6,8-9,18-19H2,(H,20,21)(H,24,25)(H,26,27),(H,6,7). InChi Key: LBSRBPSBZIUCMG-UHFFFAOYSA-N.