Pentamidine

Pentamidine is an aromatic diamine antimicrobial agent. It is a DNA minor groove binder that binds to A/T rich regions of DNA. Pentamidine is active against L. mexicana (IC50 = 4.532 µg/ml), the T. b. brucei strain S427 (IC50 = 1.1 nM), and C. neoformans (MICs = 1.56 and 6.25 µg/ml for the JEC21 and H99 strains, respectively). It increases survival in mice infected with T. b. brucei when administered at a dose of 10 µmol/kg. Formulations containing pentamidine have been used in the prevention of P. jirovecii pneumonia (PJP) in patients infected with HIV.Formal Name: 4,4'-[1,5-pentanediylbis(oxy)]bis-benzenecarboximidamide. CAS Number: 100-33-4. Synonyms: NSC 9921. Molecular Formula: C19H24N4O2. Formula Weight: 340.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 211, 265 nm. SMILES: NC(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)=N. InChi Code: InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23). InChi Key: XDRYMKDFEDOLFX-UHFFFAOYSA-N.