Pelargonidin (chloride)

Pelargonidin is an anthocyanidin that has been found in P. granatum and has diverse biological activities. It scavenges superoxide anions in cell-free assays (IC50 = 130 µg/ml) and inhibits hydrogen peroxide-induced lipid peroxidation in rat brain homogenates (IC50 = 85 µM). Pelargonidin (3 mg/kg) reduces serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), hepatocyte apoptosis, and hepatic levels of IL-1beta, IL-6, TNF-alpha, and TGF-beta in a mouse model of hepatotoxicity induced by acetaminophen (Cay-10024). It increases survival and reduces pulmonary fibrosis and leukocyte infiltration in a mouse model of LPS-induced endotoxemia. Pelargonidin (0.04-0.4 mg/kg) reduces serum levels of nitric oxide (NO), TNF-alpha, and IL-6 and increases renal myeloperoxidase (MPO), superoxide dismutase (SOD), and catalase (CAT) activities, as well as increases survival, in a mouse model of cecal ligation and puncture-induced sepsis. It also decreases escape latency in the Morris water maze, reduces hippocampal malondialdehyde (MDA) levels, and increases hippocampal acetylcholinesterase (AChE) activity in a rat model of Alzheimer's disease induced by amyloid-beta 25-35 (Abeta (25-35), Cay-24155).Formal Name: 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyrylium, monochloride. CAS Number: 134-04-3. Molecular Formula: C15H11O5 . Cl. Formula Weight: 306.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 269, 426, 524 nm. SMILES: OC1=CC(O)=C(C=C(O)C(C2=CC=C(O)C=C2)=[O+]3)C3=C1.[Cl-]. InChi Code: InChI=1S/C15H10O5.ClH/c16-9-3-1-8(2-4-9)15-13(19)7-11-12(18)5-10(17)6-14(11)20-15,/h1-7H,(H3-,16,17,18,19),1H. InChi Key: YPVZJXMTXCOTJN-UHFFFAOYSA-N.