PAP-1

PAP-1 is an inhibitor of Kv1.3 voltage-gated potassium channels (EC50 = 2 nM at -80 mV in cells overexpressing the human channel). It is selective for Kv1.3 over a panel of 22 ion channels, including potassium, sodium, calcium, and chloride channels (EC50s = 45-15,000 nM for all). PAP-1 inhibits anti-CD3 antibody-induced proliferation of isolated human CCR7- effector memory T cells. In vivo, PAP-1 (3 mg/kg) inhibits ovalbumin-induced delayed-type hypersensitivity in rats.Formal Name: 4-(4-phenoxybutoxy)-7H-furo[3,2-g][1]benzopyran-7-one. CAS Number: 870653-45-5. Synonyms: 5-(4-Phenoxybutoxy)psoralen. Molecular Formula: C21H18O5. Formula Weight: 350.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 9 mg/ml. lambdamax: 221, 249, 268, 309 nm. SMILES: O=C1C=CC(C(OCCCCOC2=CC=CC=C2)=C(C=CO3)C3=C4)=C4O1. InChi Code: InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2. InChi Key: KINMYBBFQRSVLL-UHFFFAOYSA-N.