Paeonol

Paeonol is a phenol that has been found in Paeonia and has diverse biological activities. It inhibits LPS- and IFN-gamma-induced migration and production of reactive oxygen species (ROS) in BV-2 microglia when used at concentrations of 10 and 30 µM. Paeonol inhibits histamine release from rat peritoneal mast cells induced by compound 48/80 (Cay-22173) and reduces mortality in a mouse model of compound 48/80-induced anaphylactic shock when administered at a dose of 0.5 mg per animal. It reduces hepatic necrosis and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a mouse model of hepatotoxicity induced by acetaminophen (Cay-10024) when administered at a dose of 100 mg/kg. Paeonol (30, 50, and 100 mg/kg) inhibits carrageenan-induced thermal hyperalgesia and production of nitric oxide (NO) and prostaglandin E2 (PGE2, Cay-14010) in rats.Formal Name: 1-(2-hydroxy-4-methoxyphenyl)-ethanone. CAS Number: 552-41-0. Synonyms: 2'-Hydroxy-4'-methoxyacetophenone, NSC 401442. Molecular Formula: C9H10O3. Formula Weight: 166.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMSO: 30 mg/mL, Ethanol: 30 mg/mL, Ethanol:PBS (pH7.2) (1:7): 0.12 mg/mL. lambdamax: 212, 229, 274, 314 nm. SMILES: OC1=C(C(C)=O)C=CC(OC)=C1. InChi Code: InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3. InChi Key: UILPJVPSNHJFIK-UHFFFAOYSA-N. Origin: Plant/Paeonia suffruticosa.