Oxolinic Acid

Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-stranded DNA. Oxolinic acid is a quinolone antibiotic that inhibits bacterial DNA gyrase, but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 µg/ml. Oxolinic acid also blocks neuronal uptake of dopamine in mammals (IC50 = 4.3 µM), leading to an increase in locomotor activity.Formal Name: 5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid. CAS Number: 14698-29-4. Synonyms: NSC 110364, Urinox. Molecular Formula: C13H11NO5. Formula Weight: 261.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.5 M NaOH: 50 mg/ml. lambdamax: 220, 260, 325, 335 nm. SMILES: CCN1C=C(C(O)=O)C(C2=CC3=C(OCO3)C=C21)=O. InChi Code: InChI=1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17). InChi Key: KYGZCKSPAKDVKC-UHFFFAOYSA-N.