Oxaprozin

Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 2.2 and 36 µM for human COX-1 and COX-2, respectively). It decreases acetic acid-induced writhing times and carrageenan-induced paw edema in mice when administered at doses of 100 and 70 mg/kg, respectively. Formulations containing oxaprozin have been used in the treatment of pain associated with osteoarthritis and rheumatoid arthritis.Formal Name: 4,5-diphenyl-2-oxazolepropanoic acid. CAS Number: 21256-18-8. Synonyms: NSC 310839, Wy 21743. Molecular Formula: C18H15NO3. Formula Weight: 293.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 15 mg/ml. lambdamax: 224, 288 nm. SMILES: OC(CCC1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)O1)=O. InChi Code: InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21). InChi Key: OFPXSFXSNFPTHF-UHFFFAOYSA-N.