ONC206

ONC206 is a derivative of the TRAIL-inducing compound TIC10 (Cay-16109) with anticancer activity. It induces surface expression of TNF-related apoptosis-inducing ligand (TRAIL), apoptosis, and cell cycle arrest at the G1 phase in HCT116 cells when used at a concentration of 0.05 µM. ONC206 is cytotoxic to six patient-derived diffuse intrinsic pontine glioma (DIPG) cell lines (IC50s = 0.05-0.173 µM).Formal Name: 4-[(2,4-difluorophenyl)methyl]-2,4,6,7,8,9-hexahydro-7-(phenylmethyl)-imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one. CAS Number: 1638178-87-6. Molecular Formula: C23H22F2N4O. Formula Weight: 408.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: O=C1C2=C(CCN(C2)CC3=CC=CC=C3)N4C(N1CC5=CC=C(C=C5F)F)=NCC4. InChi Code: InChI=1S/C23H22F2N4O/c24-18-7-6-17(20(25)12-18)14-29-22(30)19-15-27(13-16-4-2-1-3-5-16)10-8-21(19)28-11-9-26-23(28)29/h1-7,12H,8-11,13-15H2. InChi Key: ITMGVSSHWMTJRR-UHFFFAOYSA-N.