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Numerous analogs of arachidonoyl ethanolamide (AEA, anandamide, Cay-90050) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons or inhibition of fatty acid amide hydrolase (FAAH) within the neurons. OMDM-1 is an endocannabinoid analog specifically designed to be a potent and selective inhibitor of the cellular uptake of AEA. Structurally, OMDM-1 is the amide of (S)-tyrosinol with oleic acid (Cay-90260). In RBL-2H3 cells, OMDM-1 inhibits the cellular uptake of tritiated AEA with an IC50 of 2.4 µM, with negligible effects on the CB1 receptor and VR1.Formal Name: N-[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-9Z-octadecenamide. CAS Number: 616884-62-9. Synonyms: (S)-N-oleoyl Tyrosinol. Molecular Formula: C27H45NO3. Formula Weight: 431.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: Miscible, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 30 mg/ml. lambdamax: 225, 279 nm. SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)N[C@H](CO)Cc1ccc(O)cc1. InChi Code: InChI=1S/C27H45NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(31)28-25(23-29)22-24-18-20-26(30)21-19-24/h9-10,18-21,25,29-30H,2-8,11-17,22-23H2,1H3,(H,28,31)/b10-9-/t25-/m0/s1. InChi Key: ICDMLAQPOAVWNH-JRUKXMRZSA-N.
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