O-2545 (hydrochloride)

Cannabinoid agonists are typically highly lipophilic compounds that require solubilization with either a surfactant agent or adherence to a water miscible substance such as albumin, Tween 80, or Emulphor. O-2545 is a potent water-soluble agonist of central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 1.5 and 0.32 nM, respectively. When dissolved in saline, O-2545 was highly efficacious in mouse behavioral models when administered either intravenously or intracerebroventricularly.Formal Name: 6a,7,10,10a-tetrahydro-3-[5-(1H-imidazol-1-yl)-1,1-dimethylpentyl]-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol, monohydrochloride. CAS Number: 874745-43-4. Molecular Formula: C26H36N2O2 . HCl. Formula Weight: 445.0. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 25 mg/ml, Ethanol: 20 mg/ml. lambdamax: 230, 282 nm. SMILES: CC1=CC[C@@H]([C@@](C)(C)O2)[C@H](C3=C2C=C(C(C)(C)CCCCN4C=CN=C4)C=C3O)C1.Cl. InChi Code: InChI=1S/C26H36N2O2.ClH/c1-18-8-9-21-20(14-18)24-22(29)15-19(16-23(24)30-26(21,4)5)25(2,3)10-6-7-12-28-13-11-27-17-28,/h8,11,13,15-17,20-21,29H,6-7,9-10,12,14H2,1-5H3,1H/t20-,21-,/m1./s1. InChi Key: LSHUCXYFAOTXLT-MUCZFFFMSA-N.