Nodakenin

Nodakenin is a coumarin glucoside originally isolated from P. decursivum that has anti-inflammatory, neuroprotective, and neurogenic activities. It dose-dependently reduces LPS-induced increases in TNF-alpha, IL-6, and IL-1beta mRNA expression and protein levels and NK-kappaB activity and translocation in RAW 264.7 macrophages when used at concentrations ranging from 25 to 100 µM. Nodakenin (5, 10, and 20 mg/kg) prevents airway inflammation, hyper-responsiveness, and remodeling in a mouse model of chronic asthma induced by ovalbumin. It also decreases the levels of IL-4, IL-5, IL-13, as well as matrix metalloproteinase-2 (MMP-2) and MMP-9 in bronchoalveolar lavage fluid (BALF). Nodakenin increases proliferation of neural progenitor cells in the adult mouse hippocampal dentate gyrus, increases hippocampal protein levels of AKT and glycogen synthase kinase-3beta (GSK-3beta), and improves learning and memory in the passive avoidance test.Formal Name: (2R)-2-[1-(beta-D-glucopyranosyloxy)-1-methylethyl]-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one. CAS Number: 495-31-8. Molecular Formula: C20H24O9. Formula Weight: 408.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 50 mg/ml. lambdamax: 224, 336 nm. SMILES: O=C1C=CC2=C(C=C(O[C@@H](C(C)(C)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C4)C4=C2)O1. InChi Code: InChI=1S/C20H24O9/c1-20(2,29-19-18(25)17(24)16(23)13(8-21)28-19)14-6-10-5-9-3-4-15(22)27-11(9)7-12(10)26-14/h3-5,7,13-14,16-19,21,23-25H,6,8H2,1-2H3/t13-,14-,16-,17+,18-,19+/m1/s1. InChi Key: HXCGUCZXPFBNRD-DNLMCPORSA-N. Origin: Plant/Notopterygium incisum.