NO-Indomethacin

NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone. NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 µM, compared to >1,000 µM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.Formal Name: N-acetyl-D-cysteine-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, 4-(nitrooxy)butyl ester. CAS Number: 301838-28-8. Synonyms: NCX 2121. Molecular Formula: C28H30ClN3O9S. Formula Weight: 620.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2)(1:1): .5 mg/ml, DMSO: 20 mg/ml, Ethanol: .5 mg/ml. lambdamax: 322 nm. SMILES: O=C(C1=CC=C(Cl)C=C1)N2C3=C(C=C(OC)C=C3)C(CC(SC[C@H](N(C(C)=O)[H])C(OCCCCO[N+]([O-])=O)=O)=O)=C2C. InChi Code: InChI=1S/C28H30ClN3O9S/c1-17-22(15-26(34)42-16-24(30-18(2)33)28(36)40-12-4-5-13-41-32(37)38)23-14-21(39-3)10-11-25(23)31(17)27(35)19-6-8-20(29)9-7-19/h6-11,14,24H,4-5,12-13,15-16H2,1-3H3,(H,30,33)/t24-/m0/s1. InChi Key: VRJSAIFPCMOTPZ-DEOSSOPVSA-N.