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NNC 55-0396 is a selective inhibitor of T-type calcium channels that blocks Cav3.1 in stably expressing HEK293 cells (IC50 = 6.8 µM) with no discernible effect on high voltage-activated (L-type) channels in INS-1 cells up to a concentration of 100 µM. NNC 55-0396 suppresses tremor in two murine models, the GABAA alpha1-null (20 mg/kg) and harmaline-induced (12.5 mg/kg) tremor models, and was better tolerated than mibefradil (Cay-15037). In arterial smooth muscle cells, NCC 55-0396 (IC50 = 80 nM) inhibits voltage-dependent K+ channels but does not affect their voltage sensitivity. NNC 55-0396 (1-5 µM) also suppresses angiogenesis in vitro by inhibiting hypoxia-inducible factor-1alpha activity, and it slows tumor growth of flank xenografts of U87MG cells in mice when administered at 20 mg/kg.Formal Name: cyclopropanecarboxylic acid, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, dihydrochloride. CAS Number: 357400-13-6. Molecular Formula: C30H38FN3O2 . 2HCl. Formula Weight: 564.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, Ethanol: 30 mg/mL, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL. SMILES: FC1=CC(CC[C@@](CCN(C)CCCC2=NC(C=CC=C3)=C3N2)(OC(C4CC4)=O)[C@H]5C(C)C)=C5C=C1.Cl.Cl. InChi Code: InChI=1S/C30H38FN3O2.2ClH/c1-20(2)28-24-13-12-23(31)19-22(24)14-15-30(28,36-29(35)21-10-11-21)16-18-34(3)17-6-9-27-32-25-7-4-5-8-26(25)33-27,,/h4-5,7-8,12-13,19-21,28H,6,9-11,14-18H2,1-3H3,(H,32,33),2*1H/t28-,30-,,/m0../s1. InChi Key: BCCQNBXHUMKLFW-HNQRYHMESA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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