Nicorandil-d4

Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil (Cay-18460) by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 = 4.4 µM). It decreases mean blood pressure, coronary resistance, and heart rate, as well as increases coronary sinus outflow, in dogs when administered intravenously at a dose of 1 mg/kg. Nicorandil increases survival and decreases infarct size in a rabbit model of myocardial ischemia-reperfusion injury induced by left coronary artery occlusion. Formulations containing nicorandil have been used in the treatment of angina pectoris.Formal Name: N-[2-(nitrooxy)ethyl]-3-pyridine-2,4,5,6-d4-carboxamide. CAS Number: 1132681-23-2. Synonyms: 2-Nicotinamidoethyl nitrate-d4. Molecular Formula: C8H5D4N3O4. Formula Weight: 215.2. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(C1=C([2H])N=C([2H])C([2H])=C1[2H])NCCO[N+]([O-])=O. InChi Code: InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)/i1D,2D,3D,6D. InChi Key: LBHIOVVIQHSOQN-VTBMLFEUSA-N.