Nicergoline

Nicergoline is an antagonist of alpha1-adrenergic receptors (alpha1-ARs). It binds to alpha1-ARs in rat brain membranes (Ki = 12.5 nM) and inhibits alpha1-AR agonist-induced contractions in endothelium-denuded isolated rat aortic rings and perfused mesenteric vascular beds (pA2s = 8.6 and 11.1, respectively). In vivo, nicergoline (0.5 µg/kg per minute, i.v.) inhibits pressor responses induced by the alpha1-AR agonist cirazoline (Cay-21791) in pithed rats. Nicergoline (32 mg/kg) improves post-ischemic glutamate uptake and reduces neuronal cell death and mortality in a rat model of global brain ischemia induced by mild hyperthermia. It also increases corneal NGF levels and accelerates corneal wound healing in a rat model of ocular injury.Formal Name: (8beta)-10-methoxy-1,6-dimethyl-ergoline-8-methanol, 8-(5-bromo-3-pyridinecarboxylate). CAS Number: 27848-84-6. Synonyms: FI-6714, Nicotergoline, NSC 150531, TA-079. Molecular Formula: C24H26BrN3O3. Formula Weight: 484.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml, Ethanol: 10 mg/ml. lambdamax: 227 nm. SMILES: CO[C@@]12C3=CC=CC4=C3C(C[C@@]1([H])N(C[C@@H](C2)COC(C5=CN=CC(Br)=C5)=O)C)=CN4C. InChi Code: InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1. InChi Key: YSEXMKHXIOCEJA-FVFQAYNVSA-N.