Nevirapine

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC50 = 0.45 µM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection. Formulations containing nevirapine have been used in combination therapy for the treatment of HIV-1 infection.Formal Name: 11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one. CAS Number: 129618-40-2. Synonyms: BI-RG 587, NSC 641530, NVP. Molecular Formula: C15H14N4O. Formula Weight: 266.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 2.5 mg/ml. lambdamax: 213, 284 nm. SMILES: O=C1C2=C(N=CC=C2)N(C3CC3)C4=C(C(C)=CC=N4)N1. InChi Code: InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20). InChi Key: NQDJXKOVJZTUJA-UHFFFAOYSA-N.