Necrostatin-7

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-alpha (TNF-alpha) induced necrosis. Necrostatin-7 (Nec-7) is a necroptosis inhibitor that is structurally and biologically distinct from necrostatin-1, -3, -4, and -5 as it does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in this pathway as it inhibits TNF-alpha-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 µM.Formal Name: 5-((3-(4-fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one. CAS Number: 351062-08-3. Synonyms: Nec-7. Molecular Formula: C16H10FN5OS2. Formula Weight: 371.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Ethanol: Soluble. SMILES: O=C(N(C1=NC=CS1)C(S/2)=N)C2=C\C3=CN([H])N=C3C4=CC=C(F)C=C4. InChi Code: InChI=1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21)/b12-7-,18-15?. InChi Key: SMJGLNVGTJLIRV-KBEFMPHXSA-N.