NDI-091143

NDI-091143 is an allosteric inhibitor of ATP citrate lyase (ACL, Ki = 7 nM). It inhibits the production of ADP in a cell-free assay and oxaloacetate production in an enzyme-coupled assay (IC50s = 2.1 and 4.8 nM, respectively).Formal Name: 3-chloro-5-[[(4,6-difluoro[1,1'-biphenyl]-3-yl)amino]sulfonyl]-4-hydroxy-benzoic acid, methyl ester. CAS Number: 2375840-87-0. Molecular Formula: C20H14ClF2NO5S. Formula Weight: 453.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: slightly, DMSO: 1 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 292 nm. SMILES: O=C(C1=CC(Cl)=C(C(S(=O)(NC2=CC(C3=CC=CC=C3)=C(C=C2F)F)=O)=C1)O)OC. InChi Code: InChI=1S/C20H14ClF2NO5S/c1-29-20(26)12-7-14(21)19(25)18(8-12)30(27,28)24-17-9-13(15(22)10-16(17)23)11-5-3-2-4-6-11/h2-10,24-25H,1H3. InChi Key: YSTSHUWHIDBZAK-UHFFFAOYSA-N.