Napyradiomycin A1

Napyradiomycin A1 is a fungal metabolite originally isolated from C. rubra and has diverse biological activities. It is active against S. aureus, M. luteus, B. anthracis, C. bovis, and M. smegmatis (MICs = 1.56-12.5 µg/ml). Napyradiomycin A1 is an estrogen receptor antagonist (IC50 = 4.2 µM in rat uterine homogenates). It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 µM, respectively).Formal Name: (3R,4aR,10aS)-3,4a-dichloro-10a-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3,4,4a,10a-tetrahydro-6,8-dihydroxy-2,2-dimethyl-2H-naphtho[2,3-b]pyran-5,10-dione. CAS Number: 103106-24-7. Molecular Formula: C25H30Cl2O5. Formula Weight: 481.4. Purity: >70%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: OC1=CC(O)=C2C(C([C@@](OC(C)(C)[C@H](Cl)C3)(C/C=C(C)/CC/C=C(C)/C)[C@@]3(Cl)C2=O)=O)=C1. InChi Code: InChI=1S/C25H30Cl2O5/c1-14(2)7-6-8-15(3)9-10-25-21(30)17-11-16(28)12-18(29)20(17)22(31)24(25,27)13-19(26)23(4,5)32-25/h7,9,11-12,19,28-29H,6,8,10,13H2,1-5H3/b15-9+/t19-,24+,25+/m1/s1. InChi Key: BCPWMPCOEAOEDD-NQSCOFRMSA-N. Origin: Bacterium/Streptomyces sp..