N-trans-Caffeoyltyramine

N-trans-Caffeoyltyramine is a hydroxycinnamic acid that has been found in C. sativa and has diverse biological activities. It decreases hydrogen peroxide-induced lactate dehydrogenase (LDH) release, production of reactive oxygen species (ROS), and apoptosis in PC12 cells when used at concentrations ranging from 5 to 40 µM. N-trans-Caffeoyltyramine (50 µM) reduces tyrosinase activity and melanogenesis induced by the peptide hormone alpha-MSH (Cay-29923) in B16/F10 cells. In vivo, N-trans-caffeoyltyramine (200 mg/kg) induces intestinal expression of the gene encoding the nuclear transcription factor hepatic nuclear factor 4alpha (HNF4alpha) and increases the number of intestinal Paneth cells, a marker of intestinal barrier function, in a mouse model of high-fat diet-induced obesity.Formal Name: (2E)-3-(3,4-dihydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-propenamide. CAS Number: 103188-48-3. Synonyms: trans-N-Caffeoyltyramine, TNC, Typheramide. Molecular Formula: C17H17NO4. Formula Weight: 299.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: OC(C=C1)=CC=C1CCNC(/C=C/C2=CC(O)=C(C=C2)O)=O. InChi Code: InChI=1S/C17H17NO4/c19-14-5-1-12(2-6-14)9-10-18-17(22)8-4-13-3-7-15(20)16(21)11-13/h1-8,11,19-21H,9-10H2,(H,18,22)/b8-4+. InChi Key: VSHUQLRHTJOKTA-XBXARRHUSA-N. Origin: Plant/Litsea.