MRS1754

MRS1754 is an adenosine A2B receptor antagonist (Ki = 1.97 nM). It is selective for adenosine A2B receptors over adenosine A1, A2A, and A3 receptors (Kis = 403, 503, and 570 nM, respectively). In vivo, MRS1754 (0.5-10 mg/kg) increases 28-day survival, as well as decreases peritoneal bacterial growth and plasma levels of IL-6, TNF-alpha, and MIP-2, in a mouse model of sepsis induced by cecal ligation and puncture (CLP). MRS1754 (1 mg/kg) reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).Formal Name: N-(4-cyanophenyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide. CAS Number: 264622-58-4. Molecular Formula: C26H26N6O4. Formula Weight: 486.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml, DMSO: 0.5 mg/ml. lambdamax: 265, 319, 359 nm. SMILES: N#CC1=CC=C(NC(COC2=CC=C(C3=NC4=C(C(N(CCC)C(N4CCC)=O)=O)N3)C=C2)=O)C=C1. InChi Code: InChI=1S/C26H26N6O4/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30). InChi Key: AJBBEYXFRYFVNM-UHFFFAOYSA-N.