MreB Perturbing Compound A22

MreB is an actin-like protein expressed in bacteria. It determines the rod shape of cells and has critical roles in cell division, chromosome segregation, and cell polarity. MreB perturbing compound A22 is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly. It blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC = 3.1 µg/ml). It interferes with chromosome segregation in C. crescentus by preventing MreB binding to chromosomes. In V. cholerae, A22 prevents the development of normal cell shape and alters nucleoid morphology.Formal Name: carbamimidothioic acid,(3,4-dichlorophenyl)methyl ester, monohydrochloride. CAS Number: 22816-60-0. Molecular Formula: C8H8Cl2N2S . HCl. Formula Weight: 271.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. SMILES: ClC1=CC(CSC(N)=N)=CC=C1Cl.Cl. InChi Code: InChI=1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12,/h1-3H,4H2,(H3,11,12),1H. InChi Key: VBJNMXMOMSWRDV-UHFFFAOYSA-N.