Mn(III)TMPyP

Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O2-). Mn(III)TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M-1s-1 and ~2 x 106 M-1s-1, respectively. Mn(III)TMPyP protected and enhanced the growth of SOD null E. coli with a doubling time of 60 minutes (as compared to 240 minutes of the control) at 25 µM.Formal Name: Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin pentachloride. Molecular Formula: C44H36MnN8 . 5Cl. Formula Weight: 909.0. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.1 M Tris-HCl, 1 mM EDTA, pH 9.0: >100 mg/ml, aqueous buffers (pH 1-9): >50 mg/ml, PBS (pH 7.2): >4 mg/ml. lambdamax: 469 nm. SMILES: C[N+]1=CC=C(C=C1)C2=C(C=C3)[N]4=C3C(C5=CC=[N+](C)C=C5)=C6[N-]7[Mn+3]84[N-]9C2=CC=C9C(C(C=C%10)=CC=[N+]%10C)=C(C=C%11)[N]8=C%11C(C%12=CC=[N+](C)C=C%12)=C7C=C6.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]. InChi Code: InChI=1S/C44H36N8.5ClH.Mn/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31,,,,,,/h5-28H,1-4H3,5*1H,/q+2,,,,,,+3/p-5. InChi Key: OHZZTXYKLXZFSZ-UHFFFAOYSA-I.