ML-311

ML-311 is an inhibitor of myeloid cell leukemia-1 (Mcl-1, IC50 = 0.31 µM in a fluorescence polarization assay). It is selective for Mcl-1 over Bcl-xL (IC50 = >40 µM). ML-311 decreases the proliferation of 13 cancer cell lines (EC50s = 0.3-25 µM).Formal Name: 7-[(4-ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol. CAS Number: 315698-17-0. Molecular Formula: C23H24F3N3O. Formula Weight: 415.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 250 nm. SMILES: CCN1CCN(C(C2=C(O)C(N=CC=C3)=C3C=C2)C4=CC=C(C(F)(F)F)C=C4)CC1. InChi Code: InChI=1S/C23H24F3N3O/c1-2-28-12-14-29(15-13-28)21(17-5-8-18(9-6-17)23(24,25)26)19-10-7-16-4-3-11-27-20(16)22(19)30/h3-11,21,30H,2,12-15H2,1H3. InChi Key: NGAPBLRRJSKIRT-UHFFFAOYSA-N.