ML-243

ML-243 is an inhibitor of cancer stem cells, displaying 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 2.0 µM) over a control (mammary epithelial) cell line (EC50 = 64 µM). It weakly antagonizes the adenosine A2A receptor (IC50 = 10 µM) and has no effect on 68 other targets commonly used in drug discovery for lead profiling.Formal Name: (2E)-N-(4,5-dihydro-2-thiazolyl)-3-(4-ethylphenyl)-2-propenamide. CAS Number: 1426576-80-8. Synonyms: CID-50910523. Molecular Formula: C14H16N2OS. Formula Weight: 260.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml. lambdamax: 225, 308 nm. SMILES: CCC1=CC=C(/C=C/C(NC2=NCCS2)=O)C=C1. InChi Code: InChI=1S/C14H16N2OS/c1-2-11-3-5-12(6-4-11)7-8-13(17)16-14-15-9-10-18-14/h3-8H,2,9-10H2,1H3,(H,15,16,17)/b8-7+. InChi Key: MTLJBAFNMHPGBV-BQYQJAHWSA-N.