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The KCNQ (Kv7) family of voltage-gated potassium (K+) channels consists of five members, KCNQ1-KCNQ5. KCNQ1-KCNQ5 are critical for setting up the excitation threshold of action potentials. KCNQ1 is expressed mainly in cardiac tissue, peripheral epithelial cells, and smooth muscle cells, while KCNQ2-KCNQ5 are predominantly expressed in the peripheral and central nervous system, including hippocampal cells, cortical cells, and dorsal root ganglion. ML-213 is a selective activator of KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) channels (EC50s = 230 and 510 nM for KCNQ2 and KCNQ4, respectively) that demonstrates > 80-fold selectivity against other related K+ channels.Formal Name: N-(2,4,6-trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide. CAS Number: 489402-47-3. Synonyms: CID-3111211. Molecular Formula: C17H23NO. Formula Weight: 257.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml, Ethanol: 5 mg/ml. SMILES: CC1=CC(C)=C(NC(C2CC3CCC2C3)=O)C(C)=C1. InChi Code: InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19). InChi Key: SIQGKPGBLYKQBB-UHFFFAOYSA-N.
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