Microcystin-LA

Microcystin-LA is a cyanotoxin and an inhibitor of protein phosphatase 1C (PP1C) and PP2A (IC50 = 0.3 nM for both). In vivo, microcystin-LA (7 mg/kg) induces moribundity and increases liver-to-body weight ratios and serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST), and glutamate dehydrogenase (GDH), markers of hepatotoxicity, in mice. Microcystin-LA has been found in freshwater with cyanobacterial blooms.Formal Name: cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-beta-aspartyl-L-alanyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl]. CAS Number: 96180-79-9. Synonyms: Cyanoginosin-LA, MC-LA, Toxin BE4 (M. aeruginosa). Molecular Formula: C46H67N7O12. Formula Weight: 910.1. Purity: >95%. Formulation: (Request formulation change), A clear film. Solubility: Ethanol: Soluble, Methanol: Soluble. SMILES: CC(/C=C/[C@@H]([C@H](C)C(N[C@@H](C(O)=O)CCC(N(C)C(C(N[C@@H]1C)=O)=C)=O)=O)NC([C@H](C)NC([C@@]([H])(C)[C@H](C(O)=O)NC([C@]([H])(CC(C)C)NC1=O)=O)=O)=O)=C\[C@@H]([C@H](CC2=CC=CC=C2)OC)C. InChi Code: InChI=1S/C46H67N7O12/c1-24(2)21-35-44(60)52-38(46(63)64)28(6)40(56)47-29(7)41(57)49-33(18-17-25(3)22-26(4)36(65-11)23-32-15-13-12-14-16-32)27(5)39(55)50-34(45(61)62)19-20-37(54)53(10)31(9)43(59)48-30(8)42(58)51-35/h12-18,22,24,26-30,33-36,38H,9,19-21. InChi Key: DIAQQISRBBDJIM-DRSCAGMXSA-N.