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Methylisothiazolinone (MI) is an isothiazolinone-derived biocide. It is active against Gram-positive and Gram-negative bacteria, as well as fungi, when used in combination with methylchloroisothiazolinone (MCI) with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively. Methylisothiazolinone (50 µM) also inhibits c-Src autophosphorylation in a cell-free assay. It reduces cell viability percentage in isolated embryonic rat cortical neurons when used at a concentration of 3 µM and decreases neurite length at 1 µM. MI, alone and as a mixture with MCI, can elicit contact sensitization. Formulations containing methylisothiazolinone have been used in the control of bacteria, fungi, and algae in residential use and industry, as well as a preservative in personal care products.Formal Name: 2-methyl-3(2H)-isothiazolone. CAS Number: 2682-20-4. Synonyms: MI, MIT. Molecular Formula: C4H5NOS. Formula Weight: 115.2. Purity: >98%. Formulation: (Request formulation change), A 50% (w/v) aqueous solution. Solubility: Water: soluble. SMILES: CN1SC=CC1=O. InChi Code: InChI=1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3. InChi Key: BEGLCMHJXHIJLR-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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