Methimazole

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%. It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.Formal Name: 1,3-dihydro-1-methyl-2H-imidazole-2-thione. CAS Number: 60-56-0. Synonyms: NSC 38608. Molecular Formula: C4H6N2S. Formula Weight: 114.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: CN(C=CN1)C1=S. InChi Code: InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7). InChi Key: PMRYVIKBURPHAH-UHFFFAOYSA-N.