This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
MBQ-167 is a dual inhibitor of Rac and cell division cycle 42 (Cdc42, IC50s = 103 and 78 nM, respectively). It reduces Rac and Cdc42 GTP binding and GTPase activity and limits migration and mammosphere formation in MDA-MB-231 breast cancer cells when used at a concentration of 250 nM. MBQ-167 (250 nM), alone and in combination with the kinase inhibitor lapatinib (Cay-11493), reduces cell viability and induces apoptosis in lapatinib-resistant SK-BR-3 and MDA-MB-435 breast cancer cells. It also reduces growth rates, axial budding, and Cdc42 activity in S. cerevisiae when used at a concentration of 200 µM. Intraperitoneal administration of MBQ-167 (1 or 10 mg/kg three times per week) reduces tumor growth in an MDA-MB-435 mouse xenograft model.Formal Name: 9-ethyl-3-(5-phenyl-1H-1,2,3-triazol-1-yl)-9H-carbazole. CAS Number: 2097938-73-1. Molecular Formula: C22H18N4. Formula Weight: 338.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: CCN1C2=CC=CC=C2C3=CC(N4N=NC=C4C5=CC=CC=C5)=CC=C31. InChi Code: InChI=1S/C22H18N4/c1-2-25-20-11-7-6-10-18(20)19-14-17(12-13-21(19)25)26-22(15-23-24-26)16-8-4-3-5-9-16/h3-15H,2H2,1H3. InChi Key: LJCANTASZGYJLG-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
More information