Matrine

Matrine is an alkaloid found in S. flavescens roots that has diverse biological activities. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro. In mice, administration of matrine inhibits the development of LPS-induced hepatitis in a dose-dependent manner. Matrine reduces production of the hepatitis B surface antigen (HBsAG) and serum antigen (HBeAG) with IC50 values of 0.75 and 3.35 mg/mL, respectively, in vitro and inhibits viral replication in a duck model of hepatitis B. In vitro, matrine inhibits angiotension II-induced hyperplastic growth of cardiac fibroblasts in a dose-dependent manner. Matrine also inhibits proliferation of melanoma, breast, and colon cancer cells with IC50s ranging from 0.769-2.758 mg/ml.Formal Name: (7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one. CAS Number: 519-02-8. Synonyms: NSC 146051, NSC 318810. Molecular Formula: C15H24N2O. Formula Weight: 248.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 33.3 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C1CCC[C@@]2([H])N1C[C@@]3([H])[C@@]4([H])[C@]2([H])CCCN4CCC3. InChi Code: InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1. InChi Key: ZSBXGIUJOOQZMP-JLNYLFASSA-N.