Maribavir

Maribavir is an antiviral agent. It inhibits human cytomegalovirus (CMV) pUL97 protein kinase (IC50 = 3 nM). Maribavir inhibits the replication of clinical isolates of CMV, including those resistant to ganciclovir (Cay-37487), in infected MRC-5 human lung fibroblasts (IC50s = 0.03-0.13 µM). Oral administration of maribavir (25 or 75 mg/kg) decreases CMV titers in a mouse model of ocular CMV infection following implantation of human fetal retinal tissue. Formulations containing maribavir have been used in the treatment of post-transplant CMV infections.Formal Name: 5,6-dichloro-N -(1-methylethyl)-1-beta-L-ribofuranosyl-1H-benzimidazol-2-amine. CAS Number: 176161-24-3. Synonyms: BW 1263W94, GW 257406X, MBV. Molecular Formula: C15H19Cl2N3O4. Formula Weight: 376.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: O[C@@H]1[C@@H](N2C3=CC(Cl)=C(C=C3N=C2NC(C)C)Cl)O[C@@H](CO)[C@@H]1O. InChi Code: InChI=1S/C15H19Cl2N3O4/c1-6(2)18-15-19-9-3-7(16)8(17)4-10(9)20(15)14-13(23)12(22)11(5-21)24-14/h3-4,6,11-14,21-23H,5H2,1-2H3,(H,18,19)/t11-,12-,13-,14-/m0/s1. InChi Key: KJFBVJALEQWJBS-XUXIUFHCSA-N.