M50054

M50054 is a cell-permeable inhibitor of the activation of caspase-3, blocking characteristic features of apoptosis, including DNA fragmentation and externalization of phosphatidylserine. It blocks apoptosis in a variety of cell lines induced by different stimuli, including Fas ligand and etoposide (Cay-12092). M50054 has been used to inhibit apoptosis in skin, Xenopus larvae, teleost fish, and planaria, particularly in the context of tissue regeneration.Formal Name: 2,2'-methylenebis-1,3-cyclohexanedione. CAS Number: 54135-60-3. Molecular Formula: C13H16O4. Formula Weight: 236.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 254 nm. SMILES: O=C(CCC1)C(CC2C(CCCC2=O)=O)C1=O. InChi Code: InChI=1S/C13H16O4/c14-10-3-1-4-11(15)8(10)7-9-12(16)5-2-6-13(9)17/h8-9H,1-7H2. InChi Key: ILUMEPMGPCKGHH-UHFFFAOYSA-N.