M 344

M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1 (IC50s = 88 and 249 nM, respectively). M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 µM).Formal Name: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide. CAS Number: 251456-60-7. Synonyms: D237, Histone Deacetylase Inhibitor III, MS 344. Molecular Formula: C16H25N3O3. Formula Weight: 307.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 3 mg/ml. lambdamax: 301 nm. SMILES: ONC(=O)CCCCCCNC(=O)c1ccc(cc1)N(C)C. InChi Code: InChI=1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20). InChi Key: MXWDSZWTBOCWBK-UHFFFAOYSA-N.